Improving the Appearance of Keratosis Pilaris with Ammonia Oxidizing Bacteria
Presented at the Late-breaking Forums during the 2017 Annual Meeting in Orlando, FL, March 3-7, 2017 by:
Dr. Nicole Lee, MD, MPH
Saturday, March 4 from 10:50 AM – 11:00 AM
AUTHORS: Nicole Y Lee1, MD, MPH, Shilpi Khetarpal1, MD, Kathleen G Petrell1, Mariya Gaber2, Spiros Jamas2, ScD, Ioannis Gryllos2, PhD, D. Davidson Easson Jr2, ScD, Jeffrey S Dover1, MD, FRCPC
1 SkinCare Physicians, Chestnut Hill, MA
2AOBiome, LLC, Cambridge, MA
Keratosis pilaris is a common skin condition presenting as follicular hyperkeratotic papules on proximal extremities. The appearance is disturbing to patients and current therapies are limited. Nitric oxide (NO) is essential in systemic and cutaneous physiologic function, specifically its anti-microbial and anti-inflammatory properties, which evolutionarily may have been maintained by ammonia-oxidizing bacteria (AOB). We hypothesized that topical skin application of AOB (Nitrosomonas eutropha), a biological delivery system of nitrite and NO, could benefit KP patients. We evaluated tolerability and efficacy in a double-bind, placebo-controlled, bilateral study in subjects with KP on both arms and legs.